Stabilization of Nrf2 by tBHQ Confers Protection against Oxidative Stress-Induced Cell Death in Human Neural Stem Cells
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چکیده
منابع مشابه
Stabilization of Nrf2 by tBHQ confers protection against oxidative stress-induced cell death in human neural stem cells.
Recent studies indicate that NF-E2 related factor 2 (Nrf2) is a substrate for the ubiquitin-proteasome pathway. The present study is aimed to determine whether increased protein stability is a mechanism by which quinone compounds, like tert-butylhydroquinone (tBHQ), may enhance Nrf2-mediated transcriptional activation and subsequent antioxidant protection. H2O2-induced necrotic cell death, evid...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2004
ISSN: 1096-6080,1096-0929
DOI: 10.1093/toxsci/kfi027